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Istradefylline forty mg/day improved peak ranges and AUC of CYP3A4 substrates in medical trials. This result wasn't noticed with istradefylline 20 mg/working day. Look at dose reduction of sensitive CYP3A4 substrates.bosentan will minimize the level or influence of triazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Ch